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Major Reduction of Ultrasound-detected Synovitis During Subcutaneous Tocilizumab Treatment: Results from a Multicentre 24 Week Study of Patients with Rheumatoid Arthritis by HB Hammer; IMJ Hansen; P Järvinen; M Leirisalo-Repo; M Ziegelasch; B Agular; L Terslev is a Medicine article available to read on EtoBox.
What is Major Reduction of Ultrasound-detected Synovitis During Subcutaneous Tocilizumab Treatment: Results from a Multicentre 24 Week Study of Patients with Rheumatoid Arthritis about?
: Few studies have investigated the efficacy of subcutaneous tocilizumab (TCZ-SC) on ultrasound-detected inflammation. This study aimed to explore the clinical efficacy of TCZ-SC treatment in rheumatoid arthritis (RA) patients and to evaluate the response by ultrasound compared to Composite Disease Activity Scores (CDAS).: This open-label, single-arm study enrolled RA patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs initiating TCZ-SC 162 mg once weekly for 24 weeks, with clinical assessments at baseline, 2, 4, 8, 12, 16, 20, and 24 weeks. Ultrasound examinations [semi-quantitative score (0-3) of 36 joints and four tendons] were performed at baseline, 4, 12, and 24 weeks. CDAS and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) response, and sum scores of ultrasound grey scale/Doppler were calculated. Changes during follow-up were explored by the Mann-Whitney test and correlations by Spearman's rho.: In total, 133 patients (mean ± sd age 55.9 ± 12.0 years) were assessed clinically and 110 patients were also examined with ultrasound. All clinical and ultrasound scores decreased significantly after 4 wee
Who reads Major Reduction of Ultrasound-detected Synovitis During Subcutaneous Tocilizumab Treatment: Results from a Multicentre 24 Week Study of Patients with Rheumatoid Arthritis?
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- Author
- HB Hammer; IMJ Hansen; P Järvinen; M Leirisalo-Repo; M Ziegelasch; B Agular; L Terslev
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)