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Evaluation of Long Term Tobramycin Therapy in Patients with Cystic Fibrosis and Advanced Pulmonary Disease by U. Paporisz; H. G. Posselt; R. Wnne; W. Ristow; D. Rser; H. Knothe; S. W. Bender is a Medicine article available to read on EtoBox.

What is Evaluation of Long Term Tobramycin Therapy in Patients with Cystic Fibrosis and Advanced Pulmonary Disease about?

To nine cystic fibrosis patients with chronic bronchopulmonary infection of severely damaged lungs invaded by Pseudomonas aeruginosa, eleven courses of prolonged tobramycin treatment (5 mg/kg/day) for four to 16 weeks were administered. Pulmonary symptoms improved and a better quality of life was achieved in all but one patient. Objective parameters (chest X-ray, pulmonary function tests) changed to a lesser extent. In only one patient was Pseudomonas eradicated from the sputum but reappeared after discontinuation of therapy. In the rest of the patients Pseudomonas was significantly suppressed or replaced by other pathogens. Four patients showed rises of antibody titres to Candida and two to Aspergillus fumigatus. No nephrotoxic side effects were observed, but vestibular function was reversibly impaired in one patient without corresponding clinical symptoms. No bacterial resistance to tobramycin was observed during therapy.

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Author

U. Paporisz; H. G. Posselt; R. Wnne; W. Ristow; D. Rser; H. Knothe; S. W. Bender

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6997)

Published

1979

Language

EN

Field

Medicine (Health Sciences)