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Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p by Peng Wang; Zhiwei Wang; Min Zhang; Qi Wu; Feng Shi is a Neuroscience article available to read on EtoBox.

What is Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p about?

## Aims: Dysfunction of major cells constituting the aortic wall is the pathological basis for ad development. determining whether non-coding rnas can influence ad progression by regulating these cellular functions and identifying some specific non-coding rnas is of great significance in uncovering molecular mechanisms of the development of ad. ## Main methods: Microarray analyses and hierarchical clustering analysis were used to select candidate lncrnas and mirnas associated with ad. dual-luciferase reporter assay, rna immunoprecipitation, and rna pull-down assay were performed to verify the direct bonding relationship between genes. the regulatory effects of genes on cell function were examined in a series of experiments. ## Key findings: We found that lnc-oip5-as1 was upregulated, whereas mir-143-3p was downregulated in cells treated with angiotensin ii (angii) and ad tissues. lnc-oip5-as1 functioned as a competing endogenous rna (cerna) of mir-143-3p to suppress the proliferation and mobility, but promote apoptosis of haecs and hasmcs, and simultaneously result in the imbalances between mmp-2/9 and timp-2/1 in hasmcs and the excessive secretion of il-6, il-1β, and il-17a of haa

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Author

Peng Wang; Zhiwei Wang; Min Zhang; Qi Wu; Feng Shi

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)