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Circulating MELAN-A/MART-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype by Sushila D'Souza; Donata Rimoldi; Danielle Líénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero is a Medicine article available to read on EtoBox.

What is Circulating MELAN-A/MART-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype about?

## Melan -A/MART-1 is a melanoma differentiation antigen that is recognized by a high proportion of cytolytic T lymphocyte (CTL) clones derived from human leukocyte antigen (HLA)-A2 ϩ melanoma patients. Whereas peptide Melan-A/ MART-1 27-35 was originally defined as the immunodominant CTL epitope, we have previously reported that peptide Melan-A/MART-1 26-35 was recognized more efficiently by the majority of tumor-reactive CTL clones. As demonstrated here, CTL populations generated from blood lymphocytes of either melanoma patients or healthy individuals after in vitro stimulation with peptide Melan-A/MART-1 26-35 killed specifically HLA-A2 ϩ Melan-A ϩ allogeneic melanoma cells, thus suggesting their potential use in adoptive immunotherapy. We characterized the surface phenotype of the circulating CTL precursors (CTLp), which respond to in vitro stimulation with peptide Melan-A/MART-1 26-35 . In melanoma patients, these CTLp predominantly expressed the CD45RO memory marker. In contrast, they were mainly, although not exclusively, found in the CD45RA subpopulation of CD8 ϩ T cells in healthy individuals. The demonstration that Melan-A/MART-1-specific CTLp in peripheral blood lymphoc

Who reads Circulating MELAN-A/MART-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype?

Author

Sushila D'Souza; Donata Rimoldi; Danielle Líénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1998

Language

EN

Field

Medicine (Health Sciences)