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Enlargement of Calcium Oxalate Stones to Clinically Significant Size in an In-vitro Stone Generator by K. Ananth; J.P. Kavanagh; R.C. Walton; P.N. Rao is a Medicine article available to read on EtoBox.

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**Objective** To develop and validate an __in vitro__ method suitable for the quantitative investigation of the growth of calcium oxalate stones through to a clinically significant size. **Materials and methods** Small fragments of calcium oxalate calculi were suspended in a mixed suspension/mixed product removal crystalliser supplied with artificial urine supersaturated with calcium oxalate. The fragments were weighed at regular intervals until they reached ≈ 500 mg. The results were plotted as weight against time and fitted to equations corresponding to constant increase in diameter, surface area‐controlled and constant‐deposition growth patterns. The choice of the most appropriate model was based on the squared regression coefficient (__r__^2^). **Results** Eight fragments (2–6 mm in diameter) were grown to ≈ 10 mm in diameter over periods from 137 to 369 h. Seven of the growth curves were best‐fitted (__r__^2^ ≥ 0.988) by the equation __w = kt____^(3/2)^__ __+ c__, where __w__ is the weight, __k__ is a growth constant, __t__ is the time and __c__ is a constant approximating to the initial weight. This corresponds to a surface area‐dependent mechanism. **Conclusions** The gr

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Author

K. Ananth; J.P. Kavanagh; R.C. Walton; P.N. Rao

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

2002

Language

EN

Field

Medicine (Health Sciences)