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Distinct Array Comparative Genomic Hybridization Profiles in Oral Squamous Cell Carcinoma Occurring in Young Patients by Esther M. O'Regan; Mary E. Toner; Paul C. Smyth; Stephen P. Finn; Conrad Timon; Susanne Cahill; Richard Flavin; John J. O'Leary; Orla Sheils is a Medicine article available to read on EtoBox.
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## Background: Oral cancer typically affects smokers older than 50 years of age. recently, however, a marked increase in the number of patients 40 years old and younger, many with no history of tobacco smoking, has been noted. studies in this age group have so far been restricted to genomic areas well recognized as abnormal in typical patients with oral cancer. the aim of this study was to assess genomic aberrations in oral cancer, using comparative genomic hybridization (cgh) microarray technology, and to compare the genomic aberration profile of patients older than 40 years old with those 40 years old and younger. ## Methods: Tumor samples from 20 patients with oral cancer (age range, 21-78; 10 smokers and 10 nonsmokers) were laser microdissected, and array cgh was used to identify genomic imbalances in these two cohorts. ## Results: The older cohort showed high numbers of gains and losses in contrast to very few copy number changes in the younger nonsmoker cohort. in concurrence with the literature, tumors from the older cohort manifested deletions involving 3p and 9p21 and gains involving 3q, 5q, 7p, 8q, 11q, and 20q. the younger group, particularly the nonsmokers, showed very
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- Author
- Esther M. O'Regan; Mary E. Toner; Paul C. Smyth; Stephen P. Finn; Conrad Timon; Susanne Cahill; Richard Flavin; John J. O'Leary; Orla Sheils
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)