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Molecular characterization of human multiple myeloma cell lines by integrative genomics: Insights into the biology of the disease by Luigia Lombardi; Giulia Poretti; Michela Mattioli; Sonia Fabris; Luca Agnelli; Silvio Bicciato; Ivo Kwee; Andrea Rinaldi; Domenica Ronchetti; Donata Verdelli; Giorgio Lambertenghi‐Deliliers; Francesco Bertoni; Antonino Neri is a Medicine article available to read on EtoBox.
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## Abstract To investigate the patterns of genetic lesions in a panel of 23 human multiple myeloma cell lines (HMCLs), we made a genomic integrative analysis involving FISH, and both gene expression and genome‐wide profiling approaches. The expression profiles of the genes targeted by the main IGH translocations showed that the __WHSC1/MMSET__ gene involved in t(4;14)(p16;q32) was expressed at different levels in all of the HMCLs, and that the expression of the __MAF__ gene was not restricted to the HMCLs carrying t(14;16)(q32;q23). Supervised analyses identified a limited number of genes specifically associated with t(4;14) and involved in different biological processes. The signature related to __MAF/MAFB__ expression included the known MAF target genes __CCND2__ and __ITGB7__, as well as genes controlling cell shape and cell adhesion. Genome‐wide DNA profiling allowed the identification of a gain on chromosome arm 1q in 88% of the analyzed cell lines, together with recurrent gains on 8q, 18q, 7q, and 20q; the most frequent deletions affected 1p, 13q, 17p, and 14q; and almost all of the cell lines presented LOH on chromosome 13. Two hundred and twenty‐two genes were found to be s
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- Author
- Luigia Lombardi; Giulia Poretti; Michela Mattioli; Sonia Fabris; Luca Agnelli; Silvio Bicciato; Ivo Kwee; Andrea Rinaldi; Domenica Ronchetti; Donata Verdelli; Giorgio Lambertenghi‐Deliliers; Francesco Bertoni; Antonino Neri
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Life Sciences)