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Stimulation of μ- and δ-Opioid Receptors Enhances Phosphoinositide Metabolism in Mouse Spinal Cord: Evidence for Subtypes of δ-Receptors by Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; María-Teresa Frejo; Javier Garzón is a Neuroscience article available to read on EtoBox.
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## Abstract The accumulation of inositol phosphates (IPs) induced by agonist‐activated opioid receptors was analysed in mouse spinal cord slices pre‐labelled with myo‐[^3^H]inositol. Agonists showing selectivity to μ‐opioid receptors, morphine and [d‐Ala^2^,MePhe^4^, Gly(ol)^5^]enkephalin (DAMGO), promoted concentration‐dependent increases in the formation of IPs. The activation of δ‐opioid receptors by the selective agonists [d‐Pen^2,5^]enkephalin (DPDPE) and [d‐Ala^2^]deltorphin II produced similar increases in phosphoinositide (PI) metabolism. Pre‐treatment of the slices with pertussis toxin (PTX) blocked the effect of opioid agonists on IP production. The involvement of G~i~/G~o~‐protein (guanine nucleotide‐binding protein) classes in this opioid effect is therefore suggested. The activity of the opioid agonists was reduced by the opioid antagonists naltrexone and naloxone. The antagonist at δ~1~‐receptors, 7‐benzylidenenaltrexone (BNTX), exhibited greater potency than the antagonists at δ~2~‐receptors, naltriben methanesulphonate (NTB) or naltrindrole 5′‐isothiocyanate (NT II), in reducing the activating effect of DPDPE on phosphoinositide metabolism. Conversely, NTB and NT II
Who reads Stimulation of μ- and δ-Opioid Receptors Enhances Phosphoinositide Metabolism in Mouse Spinal Cord: Evidence for Subtypes of δ-Receptors?
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- Author
- Pilar Sánchez-Blázquez; Marta Rodríguez-Díaz; María-Teresa Frejo; Javier Garzón
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 1999
- Language
- EN
- Field
- Neuroscience (Life Sciences)