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Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals by Yujing Duan; Zeyou Chen; Lu Tan; Xiaolong Wang; Yingang Xue; Shaopeng Wang; Qing Wang; Ranjit Das; Huai Lin; Jie Hou; Linyun Li; Daqing Mao; Yi Luo is a Environmental Science article available to read on EtoBox.

What is Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals about?

Human gut microbiota is an important reservoir of antibiotic resistance genes (ARGs). Although dysbacteriosis after the antibiotic course has been previously observed in the patient guts, a comprehensive comparison of gut resistomes, microbiota and antibiotic residues in healthy individuals and patients undergoing antibiotic administration is little. Using high-throughput qPCR, 16S rRNA gene amplicon sequencing and UPLC-MS/MS, we systematically examined the antibiotic resistome, gut microbiota, and antibiotic residues in fecal samples from both Chinese healthy individuals and patients receiving antibiotic therapy. Compared with healthy individuals, patients' guts harbored lower diverse gut resistome and microbiota, but higher concentrations of antibiotics and ARGs. Antibiotic concentration in human guts was positively correlated with ARG total abundance, but was negatively related to the diversity of both ARGs and bacterial communities, which demonstrated that antibiotic administration could shape the antibiotic resistomes and bacterial communities in the patient guts. Gene cfxA was evaluated as a potential biomarker to distinguish the patients receiving antibiotic therapy from the

Who reads Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals?

Author

Yujing Duan; Zeyou Chen; Lu Tan; Xiaolong Wang; Yingang Xue; Shaopeng Wang; Qing Wang; Ranjit Das; Huai Lin; Jie Hou; Linyun Li; Daqing Mao; Yi Luo

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Environmental Science (Physical Sciences)