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Modulation of the Lifetime of Water Bound to Lanthanide Metal Ions in Complexes with Ligands Derived from 1,4,7,10-Tetraazacyclododecane Tetraacetate (DOTA) by Shanrong Zhang; Xiuyan Jiang; A. Dean Sherry is a Chemistry article available to read on EtoBox.
What is Modulation of the Lifetime of Water Bound to Lanthanide Metal Ions in Complexes with Ligands Derived from 1,4,7,10-Tetraazacyclododecane Tetraacetate (DOTA) about?
## Abstract A series of di‐ and tetraamide derivatives of DOTA were synthesized, and their lanthanide(III) complexes were examined by multinuclear ^1^H‐, ^13^C‐, and ^17^O‐NMR spectroscopy, and compared with literature data of similar, known complexes (__Table__). All ligands formed structures similar to the parent [Ln^III^(DOTA)]^−^ complexes, with four N‐atoms and four O‐atoms from DOTA and one O‐atom from the inner‐sphere water molecules. Interestingly, the lifetimes __τ__~M~ of the inner‐sphere, metal‐bound water molecules vary widely, ranging from nano‐ to milliseconds, depending on the identity of the pendent amide side chains. In general, positively charged [Ln^III^(DOTA‐tetraamide)]^3+^ complexes display the longest residence times (high __τ__~M~ values), while complexes with additional charged functional groups on the extended amides display much smaller __τ__~M~ values, even when the side groups are not directly coordinated to the central Ln^3+^ ions. The design of novel [Ln^III^(DOTA‐tetraamide)]^3+^ complexes with a wide, tunable range of __τ__~M~ values is of prime importance for the application of fast‐responding, paramagnetic chemical‐exchange‐saturation‐transfer (PA
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- Author
- Shanrong Zhang; Xiuyan Jiang; A. Dean Sherry
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0018-019X)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)