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The document discusses the limitations of positive predictive value (PPV) in noninvasive prenatal screening (NIPS) for assessing individual pregnancy risks, emphasizing that PPV is often based on averaged data and does not accurately reflect personalized risk. It proposes Z-score-based posttest risk (zPTR) as a more individualized alternative for evaluating the risk of aneuploidy in pregnancies. The authors highlight the clinical implications of relying on PPV, particularly for pregnancies with low fetal fr
- Author
- Biology Bảo
- Language
- EN