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Dipeptidyl Peptidase 3 Plasma Levels Predict Cardiogenic Shock and Mortality in Acute Coronary Syndromes by Florian A Wenzl; Francesco Bruno; Simon Kraler; Roland Klingenberg; Alexander Akhmedov; Stefano Ministrini; Karine Santos; Konstantin Godly; Julia Godly; David Niederseer; Robert Manka; Andreas Bergmann; Giovanni G Camici; Arnold von Eckardstein; Barbara Stähli; Olivier Muller; Marco Roffi; Lorenz Räber; Thomas F Lüscher is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Aims Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of angiotensin II which disturbs peripheral blood pressure regulation and compromises left ventricular function. This study examined the relationship of circulating DPP3 (cDPP3) with cardiogenic shock (CS) and mortality in patients presenting with acute coronary syndromes (ACS). ## Methods Plasma cDPP3 levels were assessed at baseline and 12–24 h after presentation in patients with ACS prospectively enrolled into the multi-centre SPUM-ACS study (n = 4787). ## Results Circulating DPP3 levels were associated with in-hospital CS when accounting for established risk factors including the ORBI risk score [per log-2 increase, hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.05–1.82, P = .021]. High cDPP3 was an independent predictor of mortality at 30 days (HR 1.87, 95% CI 1.36–2.58, P < .001) and at one year (HR 1.61, 95% CI 1.28–2.02, P < .001) after adjustment for established risk factors and the GRACE 2.0 score. Compared to values within the normal range, persistently elevated cDPP3 levels at 12–24 h were associated with 13.4-fold increased 30-day mortality risk (HR 13.42,

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Author

Florian A Wenzl; Francesco Bruno; Simon Kraler; Roland Klingenberg; Alexander Akhmedov; Stefano Ministrini; Karine Santos; Konstantin Godly; Julia Godly; David Niederseer; Robert Manka; Andreas Bergmann; Giovanni G Camici; Arnold von Eckardstein; Barbara Stähli; Olivier Muller; Marco Roffi; Lorenz Räber; Thomas F Lüscher

Publisher

Oxford University Press (OUP)

Published

2023

Field

Medicine (Health Sciences)