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Can I read Higher-order Thalamic Nuclei Facilitate the Generalization and Maintenance of Spike-and-wave Discharges of Absence Seizures on EtoBox?
Higher-order Thalamic Nuclei Facilitate the Generalization and Maintenance of Spike-and-wave Discharges of Absence Seizures by Zoe Atherton; Olivér Nagy; Lívia Barcsai; Péter Sere; Nikolett Zsigri; Tamás Földi; Levente Gellért; Antal Berényi; Vincenzo Crunelli; Magor L. Lőrincz is a Neuroscience article available to read on EtoBox.
What is Higher-order Thalamic Nuclei Facilitate the Generalization and Maintenance of Spike-and-wave Discharges of Absence Seizures about?
Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC) network, are pathological, large amplitude oscillations and the hallmark of absence seizures (ASs). SWDs begin in a cortical initiation network in both humans and animal models, including the Genetic Absence Epilepsy Rats from Strasbourg (GAERS), where it is located in the primary somatosensory cortex (S1). The behavioral manifestation of an AS occurs when SWDs spread from the cortical initiation site to the whole brain, however, the mechanisms behind this rapid propagation remain unclear. Here we investigated these processes beyond the principal CTC network, in higher-order (HO) thalamic nuclei (lateral posterior (LP) and posterior (PO) nuclei) since their diffuse connectivity and known facilitation of intracortical communications make these nuclei key candidates to support SWD generation and maintenance. In freely moving GAERS, multi-site LFP in LP, PO and multiple cortical regions revealed a novel feature of SWDs: during SWDs there are short periods (named SWD-breaks) when cortical regions far from S1, such the primary visual cortex (V1), become transiently unsynchronized from the ongoing EEG rhyth
Who reads Higher-order Thalamic Nuclei Facilitate the Generalization and Maintenance of Spike-and-wave Discharges of Absence Seizures?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Zoe Atherton; Olivér Nagy; Lívia Barcsai; Péter Sere; Nikolett Zsigri; Tamás Földi; Levente Gellért; Antal Berényi; Vincenzo Crunelli; Magor L. Lőrincz
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)