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Dextran sulfate sodium-induced colitis and ginseng intervention altered oral pharmacokinetics of cyclosporine A in rats by Ying Yang; Nan Hu; Xue-Jiao Gao; Ting Li; Zhi-Xiang Yan; Pan-Pan Wang; Bin Wei; Sai Li; Zai-Jun Zhang; Song-Lin Li; Ru Yan is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Ethnopharmacological relevance: Application of cyclosporine a (csa) as a rescue treatment in acute severe ulcerative colitis (uc) is limited by its narrow therapeutic window and great interpatient variability. as a substrate of cytochrome p450 3a enzyme (cyp3a) and p-glycoprotein (p-gp), the oral pharmacokinetics of csa is susceptible to disease status and concomitant medications. combined treatment with ginseng, a famous medicinal herb frequently prescribed for ameliorating abnormal immune response in many diseases including uc, showed immunologic safety in csa-based immunosuppression. ## Aim of the study: Since the therapeutic levels of csa can be achieved within 24 h, this study first assessed the impact of acute colitis and ginseng intervention on the single oral dose pharmacokinetics of csa and explored the underlying mechanisms in dextran sulfate sodium (dss)-induced colitis rats and caco-2 cells. ## Materials and methods: Rats received drinking water (normal group), 5% dss (uc group), or 5% dss plus daily oral ginseng extract (gs+uc group). on day 7, gs+uc group only received an oral dose of csa (5 mg/kg), while animals of normal or uc group received an oral, intravenous

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Author

Ying Yang; Nan Hu; Xue-Jiao Gao; Ting Li; Zhi-Xiang Yan; Pan-Pan Wang; Bin Wei; Sai Li; Zai-Jun Zhang; Song-Lin Li; Ru Yan

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)