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Can I read A Proteomic Investigation Into Etoposide Chemo-resistance of Neuroblastoma Cell Lines on EtoBox?
A Proteomic Investigation Into Etoposide Chemo-resistance of Neuroblastoma Cell Lines by Andrea Urbani; Julia Poland; Sergio Bernardini; Lorenza Bellincampi; Antonino Biroccio; Martina Schnölzer; Pranav Sinha; Giorgio Federici is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Proteomic Investigation Into Etoposide Chemo-resistance of Neuroblastoma Cell Lines about?
## Abstract Neuroblastoma, one of the most common pediatric solid tumors, originates from the peripheral sympathetic nervous system and is responsible for approximately 15% of all childhood cancer deaths. Among the several antineoplastic drugs used in neuroblastoma chemotherapeutic protocols, topoisomerase inhibitors (__i.e.__, etoposide) represent the most commonly used. Several resistance mechanisms limit the clinical success of topoisomerase‐targeting drugs, mainly reducing the ability of neoplastic cells to start programmed cell death when exposed to antineoplastic drugs. The aim of this study was to determine, by means of proteomics, potential markers of etoposide resistance in human neuroblastoma cell lines as well as to investigate protein levels and modifications possibly involved in the onset of resistance. The etoposide resistant clone showed overexpression of the following proteins: peroxiredoxin 1, β‐galactoside soluble lectin binding protein, vimentin (three protein spots), heat shock 27 kDa protein (two protein spots) and heterogeneous nuclear ribonucleoprotein K. In addition, we also found down‐regulation of dUTP pyrophosphatase. This investigation might represent a
Who reads A Proteomic Investigation Into Etoposide Chemo-resistance of Neuroblastoma Cell Lines?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Andrea Urbani; Julia Poland; Sergio Bernardini; Lorenza Bellincampi; Antonino Biroccio; Martina Schnölzer; Pranav Sinha; Giorgio Federici
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)