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Can I read m^6^A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway on EtoBox?
m^6^A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway by Ting Zhang; Chenbo Ding; Huifang Chen; Jun Zhao; Zhejun Chen; Baiwen Chen; Kaiqiong Mao; Yajuan Hao; Manolis Roulis; Hao Xu; Yuval Kluger; Qiang Zou; Youqiong Ye; Meixiao Zhan; Richard A. Flavell; Hua-Bing Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is m^6^A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway about?
Colonic mucosal barrier dysfunction is one of the major causes of inflammatory bowel disease (IBD). However, the mechanisms underlying mucosal barrier dysfunction are poorly understood. __N__^6^-methyladenosine (m^6^A) mRNA modification is an important modulator of epitranscriptional regulation of gene expression, participating in multiple physiological and pathological processes. However, the function of m^6^A modification in colonic epithelial cells and stem cells is unknown. Here, we show that m^6^A modification is essential for maintaining the homeostatic self-renewal in colonic stem cells. Specific deletion of the methyltransferase 14 (__Mettl14__) gene in mouse colon resulted in colonic stem cell apoptosis, causing mucosal barrier dysfunction and severe colitis. Mechanistically, we revealed that __Mettl14__ restricted colonic epithelial cell death by regulating the stability of __Nfkbia__ mRNA and modulating the NF-κB pathway. Our results identified a previously unidentified role for m^6^A modification in colonic epithelial cells and stem cells, suggesting that m^6^A modification may be a potential therapeutic target for IBD.
Who reads m^6^A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ting Zhang; Chenbo Ding; Huifang Chen; Jun Zhao; Zhejun Chen; Baiwen Chen; Kaiqiong Mao; Yajuan Hao; Manolis Roulis; Hao Xu; Yuval Kluger; Qiang Zou; Youqiong Ye; Meixiao Zhan; Richard A. Flavell; Hua-Bing Li
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)