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Can I read Gemcitabine and carboplatin in advanced transitional cell carcinoma of the urinary tract : An alternative therapy on EtoBox?
Gemcitabine and carboplatin in advanced transitional cell carcinoma of the urinary tract : An alternative therapy by Miquel Nogué-Aliguer; Joan Carles; Antonio Arrivi; Oscar Juan; Lorenzo Alonso; Albert Font; Begoña Mellado; Pilar Garrido; Alberto Sáenz is a Medicine article available to read on EtoBox.
What is Gemcitabine and carboplatin in advanced transitional cell carcinoma of the urinary tract : An alternative therapy about?
## Abstract ## BACKGROUND Cisplatin‐based combinations are considered to be the standard treatment for advanced transitional cell carcinoma (TCC) of the urothelium. Many of the patients are elderly with concomitant diseases or impaired renal function. We studied the tolerance and activity of the gemcitabine/carboplatin combination as a therapeutic alternative. ## METHODS Patients with locally advanced or metastatic TCC of the urothelium were treated with gemcitabine 1000 mg/m^2^ on Days 1 and 8 and carboplatin area under the concentration‐time curve 5 on Day 1 every 21 days. Patients with creatinine clearance of 30 mL/min or above and Karnofsky performance status (KPS) scores 60 or above were enrolled. ## RESULTS A total of 227 cycles were administered to 41 patients, with an average of 5.5 cycles per patient (range, 1–8 cycles). Creatinine clearance was below 60 mL/min in 54% of patients, KPS was 70 or below in 37% of patients, and 37% of patients were 70 years old or older. Hematologic toxicity was mainly Grade 3/4 neutropenia in 63%, Grade 3/4 thrombocytopenia in 32%, and Grade 3/4 anemia in 54% of patients. There were only three episodes of febrile neutropenia and one death fro
Who reads Gemcitabine and carboplatin in advanced transitional cell carcinoma of the urinary tract : An alternative therapy?
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- Author
- Miquel Nogué-Aliguer; Joan Carles; Antonio Arrivi; Oscar Juan; Lorenzo Alonso; Albert Font; Begoña Mellado; Pilar Garrido; Alberto Sáenz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)