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Biases in Human Papillomavirus Genotype Prevalence Assessment Associatedwith Commonly Used Consensus Primers by Paul K. S. Chan; Tak-Hong Cheung; Ann O. Y. Tam; Keith W. K. Lo; So-Fan Yim; May M. Y. Yu; Ka-Fai To; Yick-Fu Wong; Jo L. K. Cheung; Denise P. C. Chan; Mamie Hui; Margaret Ip is a Medicine article available to read on EtoBox.
What is Biases in Human Papillomavirus Genotype Prevalence Assessment Associatedwith Commonly Used Consensus Primers about?
## Abstract Consensus primers targeting human papillomaviruses (HPVs) have biases in sensitivity toward certain HPV types. We applied 3 primer sets (GP5+/6+, MY09/11, PGMY09/11) in parallel on 120 Chinese cervical cancer specimens. GP5+/6+ exhibited a poor sensitivity for HPV52, for which the prevalence among squamous cell cervical cancer was underestimated from 14.6% to 0%. The fact that HPV52 should rank second in prevalence among squamous cell cervical carcinoma in Hong Kong could be missed if GP5+/6+, a worldwide commonly used primer set, was selected for HPV detection. Biases in HPV type‐specific sensitivity may result in misprioritization of vaccine candidates. © 2005 Wiley‐Liss, Inc.
Who reads Biases in Human Papillomavirus Genotype Prevalence Assessment Associatedwith Commonly Used Consensus Primers?
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- Author
- Paul K. S. Chan; Tak-Hong Cheung; Ann O. Y. Tam; Keith W. K. Lo; So-Fan Yim; May M. Y. Yu; Ka-Fai To; Yick-Fu Wong; Jo L. K. Cheung; Denise P. C. Chan; Mamie Hui; Margaret Ip
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)