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The document details the development of a combined deposition–physiologically based pharmacokinetic (PBPK) model for inhaled treprostinil aimed at treating idiopathic pulmonary fibrosis (IPF). The model integrates lung deposition, regional tissue distribution, and systemic concentrations, demonstrating good alignment with clinical data and enabling cross-administration comparisons. It also highlights the potential for inhaled therapy to achieve comparable lung concentrations to other administration routes w
- Author
- lucasmeira.tucano
- Language
- EN