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Evaluation of the health and healthcare system burden due to antimicrobial-resistant Escherichia coli infections in humans: a systematic review and meta-analysis by MacKinnon, M. C.; Sargeant, J. M.; Pearl, D. L.; Reid-Smith, R. J.; Carson, C. A.; Parmley, E. J.; McEwen, S. A. is a Medicine article available to read on EtoBox.
What is Evaluation of the health and healthcare system burden due to antimicrobial-resistant Escherichia coli infections in humans: a systematic review and meta-analysis about?
## Abstract ## Background Assessment of the burden of disease due to antimicrobial-resistant Escherichia coli infections facilitates understanding the scale of the problem and potential impacts, and comparison to other diseases, which allows prioritization of research, surveillance, and funding. Using systematic review and meta-analysis methodology, the objectives were to evaluate whether humans with antimicrobial-resistant E. coli infections experience increases in measures of health or healthcare system burden when compared to susceptible E. coli infections. ## Methods Comprehensive literature searches were performed in four primary and seven grey literature databases. Analytic observational studies of human E. coli infections that assessed the impact of resistance to third/fourth/fifth-generation cephalosporins, resistance to quinolones, and/or multidrug resistance on mortality, treatment failure, length of hospital stay and/or healthcare costs were included. Two researchers independently performed screening, data extraction, and risk of bias assessment. When possible, random effect meta-analyses followed by assessment of the confidence in the cumulative evidence were performed
Who reads Evaluation of the health and healthcare system burden due to antimicrobial-resistant Escherichia coli infections in humans: a systematic review and meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- MacKinnon, M. C.; Sargeant, J. M.; Pearl, D. L.; Reid-Smith, R. J.; Carson, C. A.; Parmley, E. J.; McEwen, S. A.
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC (ISSN 2047-2994)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)