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Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion by Kun-Lin Wu; Chih-Jen Cheng; Chih-Chen Sung; Ming-Hua Tseng; Yu-Juei Hsu; Sung-Sen Yang; Tom Chau; Shih-Hua Lin is a Medicine article available to read on EtoBox.
What is Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion about?
## Background: Uncovering the correct diagnosis of chronic hypokalemia with potassium (k) wasting from the kidneys or gut can be fraught with challenges. we identified clinical and laboratory parameters helpful for differentiating the causes of chronic hypokalemia. ## Methods: Normotensive patients referred to our tertiary academic medical center for the evaluation of chronic hypokalemia were prospectively enrolled over 5 years. clinical features, laboratory examinations-including blood and spot urine electrolytes, acid-base status, biochemistries, and hormones-as well as genetic analysis, were determined. ## Results: Ninety-nine patients with chronic normotensive hypokalemia (serum k 2.8 ± 0.4 mmol/l, duration 4.1 ± 0.9 years) were enrolled. neuromuscular symptoms were the most common complaints. although gitelman syndrome (n = 33), bartter syndrome (n = 10), and distal renal tubular acidosis (n = 12) were the predominant renal tubular disorders, 44 patients (44%) were diagnosed with anorexia/bulimia nervosa (n = 21), surreptitious use of laxatives (n = 11), or diuretics (n = 12). patients with gastrointestinal causes and surreptitious diuretics use exhibited a female predominance
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- Author
- Kun-Lin Wu; Chih-Jen Cheng; Chih-Chen Sung; Ming-Hua Tseng; Yu-Juei Hsu; Sung-Sen Yang; Tom Chau; Shih-Hua Lin
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1555-7162)
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)