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Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease by Zhanju Liu; Li Yang; Yi Cui; Xingpeng Wang; Chuanyong Guo; Zhigang Huang; Quancheng Kan; Zhangsuo Liu; Yulan Liu is a Medicine article available to read on EtoBox.
What is Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease about?
Background: Interleukin-21 (IL-21) is involved in T and NK cell activation and effector response and promotes Th17 cell differentiation. Here we investigated IL-21 receptor (IL-21R) expression in inflamed mucosa of inflammatory bowel disease (IBD) and evaluated its role in the induction of NK cell cytotoxicity and activation as well as Th17 differentiation. Methods: Expression of IL-21R was performed by immunohistochemistry and flow cytometry. NK cell cytotoxicity was detected by a standard 51 Cr-release assay. Cytokine levels were analyzed by enzyme-linked immunosorbent assay (ELISA) and quantitative realtime polymerase chain reaction (PCR). Results: IL-21R-positive cells were significantly increased in inflamed mucosa of IBD compared with controls, and mainly expressed in freshly isolated peripheral blood (PB)-and lamina propria (LP)-CD4 ϩ , CD8 ϩ T, B, and NK cells. PB-NK cells from IBD patients produced higher levels of interferon gamma (IFN-␥) and tumor necrosis factor (TNF) than controls when stimulated with immobilized human IgG and IL-21. IL-21-primed IBD NK cells showed a more potent antitumor cytotoxicity to NK-sensitive K562 cells than controls. Moreover, PB-T and LP-T c
Who reads Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease?
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- Author
- Zhanju Liu; Li Yang; Yi Cui; Xingpeng Wang; Chuanyong Guo; Zhigang Huang; Quancheng Kan; Zhangsuo Liu; Yulan Liu
- Publisher
- John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)