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Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs by Zengfeng Pan; Xuting Xie; Yunliang Chen; Simin Pan; Zhiyun Wu; Caiyi Yang; Junjie Liang; Meilin Zhang; Qing Wang; Jinyan Chen; Lian Zhou; Xia Luo is a Medicine article available to read on EtoBox.

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## Background: Colorectal cancer is associated with ulcerative colitis (uc). the infiltration of neutrophils is the main cause of dna damage produced by inflammation in the intestinal epithelium. under the action of peptidyl arginine deaminase 4 (pad4), neutrophils dissociate chromatin and form neutrophil extracellular traps (nets), which can aggravate tissue inflammation and encourage tumor development. although huang qin decoction (hqd) was found to be useful in treating uc and was used to gradually prevent and treat digestive tract cancers, the underlying reasons were unclear. ## Methods: To demonstrate hqd could inhibits the initiation of colitis associated carcinogenesis by controlling nets related inflammation, we first performed an aom/dss-generated colitis-associated carcinogenesis model to assess the efficacy of hqd in reducing neutrophil infiltration and anti-tumor activity. then, using network pharmacology research, we investigated the potential mechanisms underlying those medicinal effects, as demonstrated by the detection of nets aggregation and pad4 expression changes in the colon. ## Results: Hqd substantially reduced the number of colon cancers and the expression of

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Author

Zengfeng Pan; Xuting Xie; Yunliang Chen; Simin Pan; Zhiyun Wu; Caiyi Yang; Junjie Liang; Meilin Zhang; Qing Wang; Jinyan Chen; Lian Zhou; Xia Luo

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Life Sciences)