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EZH2 Inhibition Enhances PARP Efficacy in Ovarian Cancer by Lorena Ramos is a document available to read on EtoBox.
What is EZH2 Inhibition Enhances PARP Efficacy in Ovarian Cancer about?
The document discusses how inhibition of EZH2 sensitizes CARM1-high epithelial ovarian cancer cells to PARP inhibition. It shows that EZH2 inhibition upregulates MAD2L2 and increases non-homologous end-joining DNA repair, causing cells to be more sensitive to PARP inhibitors. Combining EZH2 and PARP inhibitors was synergistic in suppressing tumor growth in mouse models of CARM1-high ovarian cancer.
- Author
- Lorena Ramos
- Language
- EN