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Pupil Dilation During Orienting of Attention and Conscious Detection of Visual Targets in Patients with Left Spatial Neglect by Stefano Lasaponara; Gianfranco Fortunato; David Conversi; Michele Pellegrino; Mario Pinto; Donald Louis Collins; Francesco Tomaiuolo; Fabrizio Doricchi is a Neuroscience article available to read on EtoBox.
What is Pupil Dilation During Orienting of Attention and Conscious Detection of Visual Targets in Patients with Left Spatial Neglect about?
Right Brain-Damaged patients (RBD) with left spatial neglect (N+), are characterised by deficits in orienting and re-orienting attention to stimuli in the contralesional left side of space. In a recent ERPs study with visual stimuli (Lasaponara et al., 2018) we have pointed out that the pathological attentional bias of N+ is matched with exaggerated novelty reaction and contextual updating of targets in the right ipsilesional space and reduced novelty reaction and contextual updating of targets in the left contralesional space. To characterise further the attentional performance of N+, here we measured Pupil Dilation (PDil), which is a reliable marker of noradrenergic-locus coeruleus activity and response to unexpected events/rewards. Compared to Neutral and Valid targets, N+ patients displayed a pathological reduction of PDil in response to infrequent Invalid targets in the left side of space, while in Healthy Controls (HC) and RBD without neglect (N-) the same targets enhanced PDil with respect to Neutral and frequent Valid targets. Invalid targets in the right side of space enhanced PDil in all experimental groups. Interestingly, both N- and N+ showed a consistent number of targ
Who reads Pupil Dilation During Orienting of Attention and Conscious Detection of Visual Targets in Patients with Left Spatial Neglect?
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- Author
- Stefano Lasaponara; Gianfranco Fortunato; David Conversi; Michele Pellegrino; Mario Pinto; Donald Louis Collins; Francesco Tomaiuolo; Fabrizio Doricchi
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)