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Acquisition of Humoral Immune Responses in Convalescent Japanese People with SARS-CoV-2 (COVID-19) Infection in 2021 by Koshiro Monzen; Takanori Watanabe; Toshihiro Okabe; Hisakuni Sekino; Hironori Nakagami; Ryuichi Morishita is a Medicine article available to read on EtoBox.
What is Acquisition of Humoral Immune Responses in Convalescent Japanese People with SARS-CoV-2 (COVID-19) Infection in 2021 about?
We investigated humoral immune responses in 222 unvaccinated Japanese people after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2021. Anti-spike-protein IgG antibody levels and neutralizing antibody titers were measured in serum samples obtained within 20–180 days after diagnosis. The geometric mean of antibody titers was 1555 ELU/mL (95% confidence interval (CI) = 1257–1923), and the neutralizing activity (50% inhibitory dilution) was 253 (95% CI = 204–313). The antibody titer and neutralizing activity both increased with increasing disease severity, and both values were approximately fourfold higher for hospitalized patients than for non-hospitalized patients. However, these differences were smaller in older patients. The humoral immune response, which increased with increasing disease severity, gradually decreased over time after SARS-CoV-2 infection. Most patients with mild or moderate symptoms sustained neutralizing activity for up to 180 days after the infection; the decay of the neutralizing activity in the asymptomatic patients was rather faster than in the other groups. Around 11.7% (26/222) of patients had very low neutralizing a
Who reads Acquisition of Humoral Immune Responses in Convalescent Japanese People with SARS-CoV-2 (COVID-19) Infection in 2021?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Koshiro Monzen; Takanori Watanabe; Toshihiro Okabe; Hisakuni Sekino; Hironori Nakagami; Ryuichi Morishita
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)