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MicroPET/CT In Vivo Imaging of Orthotopic Human Glioblastoma Multiforme (hGBM) Murine Model by S.S. Park; J. Chunta; I. Siiner-Grills; A.A. Martinez; G.D. Wilson; B. Marples is a Medicine article available to read on EtoBox.

What is MicroPET/CT In Vivo Imaging of Orthotopic Human Glioblastoma Multiforme (hGBM) Murine Model about?

Results: Twenty-eight patients were evaluable, all received 50.4 Gy with concurrent chemotherapy. Pneumonitis CTCAEv4 toxicity scores were: 1 grade 3, 3 grade 2, 7 grade 1, and 17 grade 0. Dosimetric factors were not predictive of symptoms. Exhaled NO measured before, at completion, and at restaging were 17.3 (SD 8.5; range 5.5 -36.7), 16.0 (14.2; 5.8 -67.7), 14.7 (6.2; 5.5 -28.0) parts per billion (ppb) respectively. Each measurement was made in triplicate with an average standard error of 0.8 ppb. The ratio of exhaled NO at the end of radiotherapy versus pre-treatment was 3.4 (1.7 -6.7) for the symptomatic and 0.8 (0.3 -1.3) for the asymptomatic (p value = 0.0017). Elevation in exhaled NO preceded peak symptoms by 33 (21 -50) days. The time to peak symptoms was found to be inversely related to the exhaled NO elevation. The exhaled NO ratio (end versus before) was tested as a predictor of symptoms using the data from this trial and the k-nearest neighbor classifier scheme described. The NO ratio predicted symptomatic patients with an average error rate of 8%. Conclusions: Elevation in the exhaled NO at the end of radiotherapy was found to predict for radiation pneumonitis symptoms

Who reads MicroPET/CT In Vivo Imaging of Orthotopic Human Glioblastoma Multiforme (hGBM) Murine Model?

Author

S.S. Park; J. Chunta; I. Siiner-Grills; A.A. Martinez; G.D. Wilson; B. Marples

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)