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The Effects of Milrinone in the Neonatal Pig Heart by Nancy T. Ross-Ascuitto; Robert J. Ascuitto; David Ramage; Kathleen H. McDonough is a Medicine article available to read on EtoBox.

What is The Effects of Milrinone in the Neonatal Pig Heart about?

Milrinone, a selective inhibitor of phosphodiesterase (PDE), was examined in neonatal hearts and in ventricular myocytes. Isolated, paced (180 beats/min), isovolumically beating hearts from pigs, less than 3 days of age, were perfused with an erythrocyte-enriched solution. In one group (control, n = 6), milrinone was studied at perfusate concentrations of 1, 10, and 100 micrograms/ml. In a second group (postischemia, n = 10), hearts were subjected to 30 minutes of no-flow ischemic arrest, prior to the addition of milrinone. Left ventricular peak systolic pressure (PSP) and end-diastolic pressure, coronary flow (CF), heart rate (HR), and myocardial oxygen consumption (MVO2) were measured. The PSP averaged approximately 100 mmHg during the baseline periods for both groups and decreased to approximately 85 mmHg in those hearts subjected to ischemic arrest. In both groups, PSP increased approximately 14% at the 1 micrograms/ml concentration of milrinone. No additional increases in PSP were observed in the control group at the higher concentrations. However, PSP increased 28% and 41% (p less than 0.05), in the postischemia group at the 10 and 100 micrograms/ml concentrations, respective

Who reads The Effects of Milrinone in the Neonatal Pig Heart?

Author

Nancy T. Ross-Ascuitto; Robert J. Ascuitto; David Ramage; Kathleen H. McDonough

Publisher

Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0920-3206)

Published

1991

Language

EN

Field

Medicine (Health Sciences)