Can I read PD.02.05 EGFR Exon 20 Insertion Mutations in a Brazilian Lung Cancer Cohort: Challenges for the Identification and Clinical Features on EtoBox?

PD.02.05 EGFR Exon 20 Insertion Mutations in a Brazilian Lung Cancer Cohort: Challenges for the Identification and Clinical Features by Izabella Negreiros; Tatiane Montella; Lucas Silva Silva; Rafael Duarte Paes; Mariano Zali; Layla Galindo; Filipe Visani; Nathalia Gimenes Afonso; Pedro De Marchi; Carlos Gil Ferreira; Rodrigo Dienstmann is a Medicine article available to read on EtoBox.

What is PD.02.05 EGFR Exon 20 Insertion Mutations in a Brazilian Lung Cancer Cohort: Challenges for the Identification and Clinical Features about?

Introduction: EGFR exon 20 insertions (ins20) are found in about 2% of non-squamous non-small cell lung cancer (nsNSCLC) patientsNovel targeted therapy approaches have significantly changed clinical outcomes in this subgroup of patients. However, for a long time, the identification of EGFR ins20 was a challenge. This study aims to describe the clinical features and assess the prevalence of EGFR ins20 in Brazilian patients with nsNSCLC using gold standard large NGS panel (GS180 Archer DNA, OCPM lab) and discordances (not detected or "false negatives") with orthogonal EGFR qPCR assay (Cobas ® ). Methods: nsNSCLC were prospectively recruited in the OCPM Lung Mapping platform from March 2020 to August 2022. The archived formalin-fixed paraffin-embedded (FFPE) tumor material was analyzed with qPCR and NGS in parallel. Epidemiological characteristics and treatment pattern data were recovered from medical records. Real world overall survival (rwOS) was defined as the date of starting treatment to the date of death or last follow-up. Results: Among the 400 cases of nsNSCLC evaluated for the EGFR gene, fifteen cases presented ins20 mutations (3.7%) by GS180. The median age was 62 years (ran

Who reads PD.02.05 EGFR Exon 20 Insertion Mutations in a Brazilian Lung Cancer Cohort: Challenges for the Identification and Clinical Features?

Author

Izabella Negreiros; Tatiane Montella; Lucas Silva Silva; Rafael Duarte Paes; Mariano Zali; Layla Galindo; Filipe Visani; Nathalia Gimenes Afonso; Pedro De Marchi; Carlos Gil Ferreira; Rodrigo Dienstmann

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)