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The document discusses the synthesis and structure-activity relationships of conformationally flexible analogues of the atypical antipsychotic sertindole, focusing on modifications to the 4-piperidinyl ring. These modifications, particularly the introduction of 2-(methylamino)ethoxy and 2-(methylamino)ethyl groups, resulted in compounds with high binding affinities for serotonin 5-HT2A and dopamine D2 receptors. The findings suggest potential for developing new antipsychotic agents with improved selectivity

Author

ananrami2008

Language

EN