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Volumetric properties of nucleic acids: Volumetric properties of nucleic acids by Tigran V. Chalikian; Kenneth J. Breslauer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Volumetric properties of nucleic acids: Volumetric properties of nucleic acids about?

Volumetric studies can yield useful new information on a myriad of intra-and intermolecular interactions that stabilize nucleic acid structures. In particular, appropriately designed volumetric measurements can characterize the conformation-dependent hydration properties of nucleic acids as a function of solution conditions, including temperature, pressure, ionic strength, pH, and cosolvent concentration. We have started to accumulate a substantial database on volumetric properties of DNA and RNA, as well as on related low molecular weight model compounds. This database already has provided unique insights into the molecular origins of various nucleic acid recognition processes, including helix-to-coil and helix-to-helix conformational transitions, as well as drug-DNA interactions. In this article, we review recent progress in volumetric investigations of nucleic acids, emphasizing how these data can be used to gain insight into intra-and intermolecular interactions, including hydration properties. Throughout this review, we underscore the importance of volume and compressibility data for characterizing the hydration properties of nucleic acids and their constituents. We also descr

Who reads Volumetric properties of nucleic acids: Volumetric properties of nucleic acids?

Author

Tigran V. Chalikian; Kenneth J. Breslauer

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)