Can I read Targeted Therapy of Colorectal Cancer Subtypes Volume 1110 on EtoBox?

Targeted Therapy of Colorectal Cancer Subtypes Volume 1110 by Jordan, Peter is a scholarly article available to read on EtoBox.

What is Targeted Therapy of Colorectal Cancer Subtypes Volume 1110 about?

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Recent years have increased significantly our understanding of the genetic alterations that can underlie CRC, but also unraveled the molecular heterogeneity of the disease. Although a simple correlation between genetic pathways, histopathological features and clinical outcome cannot be established, the heterogeneity of CRC is also an opportunity for the development of targeted therapeutic approaches, able to treat an individual tumor with higher efficiency and less toxic side effects. One CRC subtype is characterized by high mutation rates (MSI-H), DNA methylation changes (CIMP-H), mutation in the BRAF oncogene and occurrence of serrated adenomas in the proximal colon. Other groups prevail in the distal colon and consist of either adenomatous polyps with chromosomal aberrations (CIN) and WNT pathway activation, or carry frequent KRAS mutation and metabolic deregulation, or have strong mesenchymal and infiltrative characteristics. Characterization of driver-mutation events in these CRC subgroups has led to the development of specific drugs targeting, for example, the MAPK pathway, but initial clinical tria

Author

Jordan, Peter

Publisher

Springer International Publishing : Imprint: Springer

Published

2018

Language

EN

ISBN

9783030027704