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Low Seroprevalence of SARS-CoV-2 Antibodies during Systematic Antibody Screening and Serum Responses in Patients after COVID-19 in a German Transplant Center by Choi, Mira; Bachmann, Friederike; Naik, Marcel Ganesh; Duettmann, Wiebke; Duerr, Michael; Zukunft, Bianca; Schwarz, Tatjana; Corman, Victor Max; Liefeldt, Lutz; Budde, Klemens; Halleck, Fabian is a Medicine article available to read on EtoBox.
What is Low Seroprevalence of SARS-CoV-2 Antibodies during Systematic Antibody Screening and Serum Responses in Patients after COVID-19 in a German Transplant Center about?
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 denotes a global health issue. Data regarding COVID-19 incidence in kidney transplant recipients (KTR) are sparse. From 19 March to 19 May 2020, we performed a systematic screening for COVID-19 in KTR. Tests included serum analysis for SARS-CoV-2 antibodies using S protein-based immunofluorescence, anti-SARS-CoV-2 S1 immunoglobulin G (IgG) and immunoglobulin A (IgA) enzyme-linked immunosorbent assays (ELISA), and/or quantitative reverse transcription polymerase chain reaction (qRT-PCR) from nasal-throat swabs. Outpatient serum samples from KTR with PCR confirmed COVID-19, and swab samples from recipients (+donors) undergoing kidney transplantation were analyzed. Out of 223 samples from outpatients, 13 patients were positive with solely anti-SARS-CoV-2-IgA and 3 with both anti-IgA and anti-IgG. In total, 53 patients were symptomatic in the past, but positive results could be found in both symptomatic and asymptomatic patients. After an in depth analysis using immunofluorescence and neutralization tests in 2 KTR, recent COVID-19 infection remained highly suspicious. Apart from outpatient visits, only 5 out of 2044
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- Author
- Choi, Mira; Bachmann, Friederike; Naik, Marcel Ganesh; Duettmann, Wiebke; Duerr, Michael; Zukunft, Bianca; Schwarz, Tatjana; Corman, Victor Max; Liefeldt, Lutz; Budde, Klemens; Halleck, Fabian
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI) (ISSN 2077-0383)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)