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Extent of Protein–protein Interactions and Quasi‐equivalence in Viral Capsids by Craig M. Shepherd; Vijay S. Reddy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Viral capsids are composed of multiple copies of one or a few gene products that self‐assemble on their own or in the presence of the viral genome and/or auxiliary proteins into closed shells (capsids). We have analyzed 75 high‐resolution virus capsid structures by calculating the average fraction of the solvent‐accessible surface area of the coat protein subunits buried in the viral capsids. This fraction ranges from 0 to 1 and represents a normalized protein–protein interaction (PPI) index and is a measure of the extent of protein–protein interactions. The PPI indices were used to compare the extent of association of subunits among different capsids. We further examined the variation of the PPI indices as a function of the molecular weight of the coat protein subunit and the capsid diameter. Our results suggest that the PPI indices in T=1 and __pseudo__‐T=3 capsids vary linearly with the molecular weight of the subunit and capsid size. This is in contrast to quasi‐equivalent capsids with T≥3, where the extent of protein–protein interactions is relatively independent of the subunit and capsid sizes. The striking outcome of this analysis is the distinctive clustering of

Who reads Extent of Protein–protein Interactions and Quasi‐equivalence in Viral Capsids?

Author

Craig M. Shepherd; Vijay S. Reddy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)