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The effect of the 5‐HT~3~ receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients by E. A. Mayer; S. Berman; S. W. G. Derbyshire; B. Suyenobu; L. Chang; L. Fitzgerald; M. Mandelkern; L. Hamm; B. Vogt; B. D. Naliboff is a Medicine article available to read on EtoBox.

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## Summary **Aim** : To conduct a placebo‐controlled functional brain imaging study to assess the effect of the 5‐hydroxytryptamine‐3 receptor antagonist, alosetron, on irritable bowel syndrome symptoms, regional brain activation by rectosigmoid distension and associated perceptual and emotional responses. **Methods** : Fifty‐two non‐constipated irritable bowel syndrome patients (28 female) were enrolled in a randomized, placebo‐controlled trial with alosetron (1–4 mg b.d.). Thirty‐seven patients completed both brain scans following randomization. Rectosigmoid stimulation was performed with a computer‐controlled barostat. Changes in regional cerebral blood flow were assessed using __H__~2~^15^O positron emission tomography. Stimulus ratings and changes in gastrointestinal symptoms were assessed using verbal descriptor scales. **Results** : Alosetron, but not placebo, treatment was associated with a decrease in symptom ratings, and reductions in emotional stimulus ratings. Compared to baseline, alosetron treatment was associated with reduced regional cerebral blood flow in bilateral frontotemporal and various limbic structures, including the amygdala. Compared to placebo, decreases

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Author

E. A. Mayer; S. Berman; S. W. G. Derbyshire; B. Suyenobu; L. Chang; L. Fitzgerald; M. Mandelkern; L. Hamm; B. Vogt; B. D. Naliboff

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2002

Language

EN

Field

Medicine (Health Sciences)