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Can I read Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis on EtoBox?
Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis by Anna Niechcial; Marlene Schwarzfischer; Marcin Wawrzyniak; Kirstin Atrott; Andrea Laimbacher; Yasser Morsy; Egle Katkeviciute; Janine Häfliger; Patrick Westermann; Cezmi A Akdis; Michael Scharl; Marianne R Spalinger is a Medicine article available to read on EtoBox.
What is Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis about?
## Abstract ## Background and Aims Exacerbated immune activation, intestinal dysbiosis and a disrupted intestinal barrier are common features among inflammatory bowel disease [IBD] patients. The polyamine spermidine, which is naturally present in all living organisms, is an integral component of the human diet, and exerts beneficial effects in human diseases. Here, we investigated whether spermidine treatment ameliorates intestinal inflammation and offers therapeutic potential for IBD treatment. ## Methods We assessed the effect of oral spermidine administration on colitis severity in the T cell transfer colitis model in Rag2^−/−^ mice by endoscopy, histology and analysis of markers of molecular inflammation. The effects on the intestinal microbiome were determined by 16S rDNA sequencing of mouse faeces. The impact on intestinal barrier integrity was evaluated in co-cultures of patient-derived macrophages with intestinal epithelial cells. ## Results Spermidine administration protected mice from intestinal inflammation in a dose-dependent manner. While T helper cell subsets remained unaffected, spermidine promoted anti-inflammatory macrophages and prevented the microbiome shift from
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- Author
- Anna Niechcial; Marlene Schwarzfischer; Marcin Wawrzyniak; Kirstin Atrott; Andrea Laimbacher; Yasser Morsy; Egle Katkeviciute; Janine Häfliger; Patrick Westermann; Cezmi A Akdis; Michael Scharl; Marianne R Spalinger
- Publisher
- Oxford University Press (OUP)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)