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Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa by Thomas E Renau; Roger Léger; Lubov Filonova; Eric M Flamme; Michael Wang; Rose Yen; Deidre Madsen; David Griffith; Suzanne Chamberland; Michael N Dudley; Ving J Lee; Olga Lomovskaya; William J Watkins; Toshiharu Ohta; Kiyoshi Nakayama; Yohei Ishida is a scholarly article available to read on EtoBox.

What is Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa about?

Conformational restriction of the ornithine residue of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595, 2) furnished bioisosteric proline derivatives that were less toxic in vivo and as active as the lead in potentiating the activity of the fluoroquinolone levofloxacin via the inhibition of efflux pumps in Pseudomonas aeruginosa.

Author

Thomas E Renau; Roger Léger; Lubov Filonova; Eric M Flamme; Michael Wang; Rose Yen; Deidre Madsen; David Griffith; Suzanne Chamberland; Michael N Dudley; Ving J Lee; Olga Lomovskaya; William J Watkins; Toshiharu Ohta; Kiyoshi Nakayama; Yohei Ishida

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2003

Language

EN