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Can I read Multipoint Oligogenic Linkage Analysis of Quantitative Traits on EtoBox?
Multipoint Oligogenic Linkage Analysis of Quantitative Traits by John Blangero; Laura Almasy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Multipoint Oligogenic Linkage Analysis of Quantitative Traits about?
We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic analyses was found to have increased power to detect the three quantitative trait loci (QTL) influencing Q4 when compared to the classical marginal approach of requiring each locus to have a lod score $ 3. However, it is shown that requiring conditional lod scores $ 3 in the sequential analyses may be overly conservative and alternative criteria for the acceptance of multilocus models are discussed.
Who reads Multipoint Oligogenic Linkage Analysis of Quantitative Traits?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- John Blangero; Laura Almasy
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)
- Published
- 1997
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)