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Can I read Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimodal Therapy on EtoBox?
Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimodal Therapy by Oluwaseun O. Akinduro; Paola Suarez-Meade; Diogo Garcia; Desmond A. Brown; Rachel Sarabia-Estrada; Steven Attia; Ziya L. Gokaslan; Alfredo Quiñones-Hinojosa is a Medicine article available to read on EtoBox.
What is Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimodal Therapy about?
Background Chordoma is a rare but devastating tumor that arises in the cranial skull base or spine. There are currently no US Food and Drug Administration-approved targeted therapies for chordoma, and little understanding of whether using more than one therapy has benefit over monotherapy. Objective The objective of this study was to systematically review the current status of clinical trials completed for patients with chordoma to determine if multimodal therapy offers a benefit in progression-free survival over monomodal therapy. Methods We performed a systematic review of the literature according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines to review the available clinical trials of targeted therapy for chordoma. We compiled the clinical data to determine if there is a benefit of multimodal therapy over monotherapy. Results Our search resulted in 11 clinical trials including 270 patients with advanced chordoma who were treated with targeted therapies. The most commonly employed targeted therapies acted within the following pathways: platelet-derived growth factor receptor (187 patients), vascular endothelial growth factor (66 patients
Who reads Targeted Therapy for Chordoma: Key Molecular Signaling Pathways and the Role of Multimodal Therapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Oluwaseun O. Akinduro; Paola Suarez-Meade; Diogo Garcia; Desmond A. Brown; Rachel Sarabia-Estrada; Steven Attia; Ziya L. Gokaslan; Alfredo Quiñones-Hinojosa
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)