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Phase-Amplitude Coupling of the Electroencephalogram in the Auditory Cortex in Schizophrenia by Shogo Hirano; Alexander Nakhnikian; Yoji Hirano; Naoya Oribe; Shigenobu Kanba; Toshiaki Onitsuka; Margaret Levin; Kevin M. Spencer is a Neuroscience article available to read on EtoBox.

What is Phase-Amplitude Coupling of the Electroencephalogram in the Auditory Cortex in Schizophrenia about?

## Background: Cross-frequency interactions may coordinate neural circuits operating at different frequencies. while neural oscillations associated with particular circuits in schizophrenia (sz) are impaired, few studies have examined cross-frequency interactions. here we examined phase-amplitude coupling (pac) in the electroencephalograms of individuals with sz and healthy control subjects (hcs). we computed pac during the baseline period of 40-hz auditory steady-state stimulation and rest. we hypothesized that subjects with sz would show abnormal theta/gamma coupling during stimulation, especially in the left auditory cortex, and coupling with high frequencies would be higher during stimulation than during rest. ## Methods: We reanalyzed data from 18 subjects with sz and 18 hcs. auditory cortex electroencephalogram activity was estimated using dipole source localization. pac was computed using the debiased pac measure, calculated with the generalized morse wavelet transform. pac clusters were identified using cluster-corrected permutation testing and interrogated in analyses of variance with correction for multiple tests. ## Results: Overall, coupling of high beta and gamma ampli

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Author

Shogo Hirano; Alexander Nakhnikian; Yoji Hirano; Naoya Oribe; Shigenobu Kanba; Toshiaki Onitsuka; Margaret Levin; Kevin M. Spencer

Published

2018

Language

EN

Field

Neuroscience (Life Sciences)