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Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma by Wissam Farhat; Vincent Yeung; Francesca Kahale; Mohit Parekh; John Cortinas; Lin Chen; Amy E. Ross; Joseph B. Ciolino is a Medicine article available to read on EtoBox.

What is Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma about?

Chemotherapy is often used to treat retinoblastoma; however, this treatment method has severe systemic adverse effects and inadequate therapeutic effectiveness. Extracellular vesicles (EVs) are important biological information carriers that mediate local and systemic cell-to-cell communication under healthy and pathological settings. These endogenous vesicles have been identified as important drug delivery vehicles for a variety of therapeutic payloads, including doxorubicin (Dox), with significant benefits over traditional techniques. In this work, EVs were employed as natural drug delivery nanoparticles to load Dox for targeted delivery to retinoblastoma human cell lines (Y-79). Two sub-types of EVs were produced from distinct breast cancer cell lines (4T1 and SKBR3) that express a marker that selectively interacts with retinoblastoma cells and were loaded with Dox, utilizing the cells’ endogenous loading machinery. In vitro, we observed that delivering Dox with both EVs increased cytotoxicity while dramatically lowering the dosage of the drug. Dox-loaded EVs, on the other hand, inhibited cancer cell growth by activating caspase-3/7. Direct interaction of EV membrane moieties wit

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Author

Wissam Farhat; Vincent Yeung; Francesca Kahale; Mohit Parekh; John Cortinas; Lin Chen; Amy E. Ross; Joseph B. Ciolino

Publisher

MDPI AG

Published

2022

Language

EN

Field

Medicine (Health Sciences)