Opening book details…
Can I read T Cell Characteristics Associated with Toxicity to Immune Checkpoint Blockade in Patients with Melanoma on EtoBox?
T Cell Characteristics Associated with Toxicity to Immune Checkpoint Blockade in Patients with Melanoma by Alexander X. Lozano; Aadel A. Chaudhuri; Aishwarya Nene; Antonietta Bacchiocchi; Noah Earland; Matthew D. Vesely; Abul Usmani; Brandon E. Turner; Chloé B. Steen; Bogdan A. Luca; Ti Badri; Gunsagar S. Gulati; Milad R. Vahid; Farnaz Khameneh; Peter K. Harris; David Y. Chen; Kavita Dhodapkar; Mario Sznol; Ruth Halaban; Aaron M. Newman is a Medicine article available to read on EtoBox.
What is T Cell Characteristics Associated with Toxicity to Immune Checkpoint Blockade in Patients with Melanoma about?
Severe immune-related adverse events (irAEs) occur in up to 60% of patients with melanoma treated with immune checkpoint inhibitors (ICIs). However, it is unknown whether a common baseline immunological state precedes irAE development. Here we applied mass cytometry by time of flight, single-cell RNA sequencing, single-cell V(D)J sequencing, bulk RNA sequencing and bulk T cell receptor (TCR) sequencing to study peripheral blood samples from patients with melanoma treated with anti-PD-1 monotherapy or anti-PD-1 and anti-CTLA-4 combination ICIs. By analyzing 93 pre- and early on-ICI blood samples and 3 patient cohorts (n = 27, 26 and 18), we found that 2 pretreatment factors in circulation-activated CD4 memory T cell abundance and TCR diversity-are associated with severe irAE development regardless of organ system involvement. We also explored on-treatment changes in TCR clonality among patients receiving combination therapy and linked our findings to the severity and timing of irAE onset. These results demonstrate circulating T cell characteristics associated with ICI-induced toxicity, with implications for improved diagnostics and clinical management.
Who reads T Cell Characteristics Associated with Toxicity to Immune Checkpoint Blockade in Patients with Melanoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alexander X. Lozano; Aadel A. Chaudhuri; Aishwarya Nene; Antonietta Bacchiocchi; Noah Earland; Matthew D. Vesely; Abul Usmani; Brandon E. Turner; Chloé B. Steen; Bogdan A. Luca; Ti Badri; Gunsagar S. Gulati; Milad R. Vahid; Farnaz Khameneh; Peter K. Harris; David Y. Chen; Kavita Dhodapkar; Mario Sznol; Ruth Halaban; Aaron M. Newman
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)