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Premature ovarian insufficiency and chance of pregnancy after childhood cancer: A population‐based study (the Fex‐Can study) by Anu Haavisto; Lena Wettergren; Claudia Lampic; Päivi M. Lähteenmäki; Kirsi Jahnukainen is a Medicine article available to read on EtoBox.
What is Premature ovarian insufficiency and chance of pregnancy after childhood cancer: A population‐based study (the Fex‐Can study) about?
Endocrine complications are a common late effect after childhood cancer. Our study assessed the prevalence and predictors of premature ovarian insufficiency (POI) and prospects of pregnancy in young female survivors. This nationwide study combined registry and survey data for female childhood cancer survivors aged 19 to 40 years, identified through the National Quality Registry for Childhood Cancer in Sweden. Of 1989 approached young women, 1333 (67%) participated by completing a survey.Median age at diagnosis 1981 to 2017 was 6 (range 0-17) and at study 28 (19-40) years. There were two indicators of POI, induced puberty reported in 5.3% and estrogen replacement therapy (ERT) in 9.3% at assessment. In separate logistic regression analyses (P < .001), induced puberty and ERT were significantly predicted by hematopoietic stem cell transplantation (HSCT), abdominal irradiation, central nervous system irradiation and chemotherapy. ERT was also associated with older age at diagnosis. Of the 626 women (48% of responders) who had tried to become pregnant, 25% had undergone fertility investigations and 72% reported having a biological child. Treatment with HSCT was associated with 5.4 time
Who reads Premature ovarian insufficiency and chance of pregnancy after childhood cancer: A population‐based study (the Fex‐Can study)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anu Haavisto; Lena Wettergren; Claudia Lampic; Päivi M. Lähteenmäki; Kirsi Jahnukainen
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)