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CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA) by Rocio Garcia-Santibanez; Craig M. Zaidman; R. Brian Sommerville; Glenn Lopate; Conrad C. Weihl; Alan Pestronk; Robert C. Bucelli is a Medicine article available to read on EtoBox.

What is CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA) about?

## Introduction: Canomad/canda are syndromes characterized by ataxic neuropathy, ophthalmoplegia, monoclonal gammopathy, cold agglutinins and disialosyl antibodies. ## Methods: A retrospective review of our neuromuscular autoantibody panel database was performed. anti-gd1b seropositive patients with ataxia were included. ## Results: Eleven patients were identified. median age at onset was 56 years. median disease duration was 6 years. all patients had gait disorders. nine had ocular motility abnormalities. most had a monoclonal protein and all had elevated serum igm. electrodiagnostic studies showed a mixed axonal/demyelinating pattern (6), an axonal pattern (4), or a pure demyelinating pattern (1). ultrasounds showed nerve enlargement patterns consistent with acquired demyelination. a nerve biopsy showed near complete loss of myelinated axons with preservation of smaller axons. rituximab was the most effective immunotherapy. ## Conclusion: Canomad/canda are rare and debilitating disorders with characteristic clinical and diagnostic findings. in our cohort, nerve ultrasound showed regional nerve enlargement and rituximab was the most effective immunomodulatory therapy.

Who reads CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA)?

Author

Rocio Garcia-Santibanez; Craig M. Zaidman; R. Brian Sommerville; Glenn Lopate; Conrad C. Weihl; Alan Pestronk; Robert C. Bucelli

Publisher

Springer Science and Business Media LLC

Published

2018

Language

EN

Field

Medicine (Health Sciences)