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Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians†‡ by Robert L. Hanson; Giuseppina Imperatore; K. M. Venkat Narayan; Janine Roumain; Anne Fagot‐Campagna; David J. Pettitt; Peter H. Bennett; William C. Knowler is a Medicine article available to read on EtoBox.

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## Abstract ## Background The present analyses were conducted to examine the extent to which insulin sensitivity and insulin secretion, assessed using simple indices derived from an oral glucose tolerance test, are influenced by genetic factors, and to assess whether these genetic factors overlap with those influencing susceptibility to type 2 diabetes in Pima Indians. ## Methods Indices calculated from fasting and 2‐h post‐load insulin (__I__~0~, __I__~120~) and glucose (__G__~0~, __G__~120~) concentrations included insulin sensitivity index [__ISI__~0~=10^4^/(__I__~0~·__G__~0~)] and corrected insulin response {__CIR__~120~=__I__~120~/[__G__~120~·(__G__~120~–70 mg/dl)]}. Heritability (__h__^2^) was determined using variance components methods in 1421 non‐diabetic individuals from 446 sibships. Among 595 individuals in 186 sibships, genome‐wide quantitative trait linkage analyses of __ISI__~0~ and __CIR__~120~ were conducted and affected‐sibling analyses of diabetic siblings stratified by prediabetic measurements of __ISI__~0~ and __CIR__~120~ were also performed. ## Results Both __ISI__~0~ (__h__^2^=0.37±0.06) and __CIR__~120~ (__h__^2^=0.25±0.07) were moderately heritable. Modest

Who reads Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians†‡?

Author

Robert L. Hanson; Giuseppina Imperatore; K. M. Venkat Narayan; Janine Roumain; Anne Fagot‐Campagna; David J. Pettitt; Peter H. Bennett; William C. Knowler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-7552)

Published

2001

Language

EN

Field

Medicine (Health Sciences)