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Clotrimazole: A Review of its Antifungal Activity and Therapeutic Efficacy by Phyllis R. Sawyer; R. N. Brogden; R. M. Pinder; T. M. Speight; G. S. Avery is a Medicine article available to read on EtoBox.

What is Clotrimazole: A Review of its Antifungal Activity and Therapeutic Efficacy about?

Clotrimazole 2, a synthetic imidazole derivative, is primarily used locally in the treatment of vaginal and skin infections due to yeasts and dermatophytes. In vitro, it is most active against Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia fuffur (Pityrosporon orbiculare). In addition, it has some in vitro activity against certain Gram-positive bacteria, and at very high concentrations has activity against Trichomonas spp. In the treatment of vaginal candidiasis, clotrimazole vaginal tablets have produced cure rates comparable with those of conventional nystatin vaginal tablets. There have been no published comparisons with nystatin vaginal cream or foaming vaginal tablets - nystatin dosage forms preferred by some clinicians. Cootrimazole has also been successful in patients who had failed to respond to other antifungal agents such as nystatin and amphotericin B. Results in trichomonal vaginitis are not impressive. Skin infections caused by Candida or dermatophytes have been effectively treated with topical application of clotrimazole. In comparative trials, clotrimazole cream has been as effective as Whitfield's ointment and tolnaftate in the treatment of dermato

Who reads Clotrimazole: A Review of its Antifungal Activity and Therapeutic Efficacy?

Author

Phyllis R. Sawyer; R. N. Brogden; R. M. Pinder; T. M. Speight; G. S. Avery

Publisher

Springer Science and Business Media LLC

Published

1975

Language

EN

Field

Medicine (Health Sciences)