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The research paper presents the discovery of MS8847, a novel and highly potent EZH2 PROTAC degrader that effectively targets both canonical and non-canonical oncogenic functions of EZH2, implicated in various cancers. MS8847 demonstrates superior EZH2 degradation and anti-proliferative effects in MLL-rearranged acute myeloid leukemia and triple-negative breast cancer cell lines compared to previously reported degraders. This compound has a pharmacokinetic profile suitable for in vivo studies, making it a va

Author

Nguyễn Đức Thiện

Language

EN