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Uropathogenic Bacteria and Deductive Genomics Towards Antimicrobial Resistance, Virulence, and Potential Drug Targets by Aaima Amin; Ramisha Noureen; Ayesha Iftikhar; Annam Hussain; Wadi B. Alonazi; Hafiz Muhammad Zeeshan Raza; Ifra Ferheen; Muhammad Ibrahim is a scholarly article available to read on EtoBox.

What is Uropathogenic Bacteria and Deductive Genomics Towards Antimicrobial Resistance, Virulence, and Potential Drug Targets about?

Urinary tract infections (UTIs) are among the most prevalent bacterial infections affecting people in inpatient and outpatient settings. The current study aimed to sequence the genome of uropathogenic Escherichia coli strain CUI-B1 resourced from a woman having uncomplicated cystitis and pyelonephritis. Followed by deductive genomics towards potential drug targets using E. coli strain CUI-B1, strain O25b: H4-ST131, Proteus mirabilis strain HI4320, Klebsiella pneumoniae strain 1721, and Staphylococcus saprophyticus strain ATCC 15305 uropathogenic strains. Comparative genome analysis revealed that genes related to the survival of E. coli, P. mirabilis, K. pneumoniae, and S. saprophyticus, such as genes of metal-requiring proteins, defense-associated genes, and genes associated with general physiology, were found to be highly conserved in the genomes including strain CUI-B1. However, the genes responsible for virulence and drug resistance, mainly those that are involved in bacterial secretion, fimbriae, adherence, and colonization, were found in various genomic regions and varied from one species to another or within the same species. Based on the genome sequence, virulence, and antim

Author

Aaima Amin; Ramisha Noureen; Ayesha Iftikhar; Annam Hussain; Wadi B. Alonazi; Hafiz Muhammad Zeeshan Raza; Ifra Ferheen; Muhammad Ibrahim

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN