Can I read The Human Peripheral Blood Mononuclear Cell Proteome Responds to a Dietary Flaxseed-intervention and Proteins Identified Suggest a Protective Effect in Atherosclerosis on EtoBox?

The Human Peripheral Blood Mononuclear Cell Proteome Responds to a Dietary Flaxseed-intervention and Proteins Identified Suggest a Protective Effect in Atherosclerosis by Dagmar Fuchs; Regina Piller; Jakob Linseisen; Hannelore Daniel; Uwe Wenzel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Human Peripheral Blood Mononuclear Cell Proteome Responds to a Dietary Flaxseed-intervention and Proteins Identified Suggest a Protective Effect in Atherosclerosis about?

## Abstract Flaxseed is one of the richest sources of lignans that are converted to enterolactone by the intestinal microflora. Enterolactone has been suggested to be the prime active compound mediating atherosclerosis‐protective effects that were shown for flaxseed. The effects of a 1‐wk intervention with 0.4 g of flaxseed/kg body weight __per__ day on enterolactone plasma levels in seven healthy men revealed that all participants (PAs) responded with enhanced enterolactone plasma levels. Proteome analysis of peripheral blood mononuclear cells (PBMC) from donors before, during, and after the intervention showed that flaxseed consumption affected significantly the steady‐state levels of 16 proteins of which four were altered in a similar manner when blood mononuclear cells were exposed __ex vivo__ to enterolactone. Enhanced levels of peroxiredoxin and reduced levels of the long‐chain fatty acid β‐oxidation multienzyme complex may be taken as indicators of a reduced oxidative stress whereas reduced levels of glycoprotein IIIa/II could indicate improved protection from thrombotic and inflammatory processes. In conclusion, the blood mononuclear cell proteome responds to dietary flaxse

Who reads The Human Peripheral Blood Mononuclear Cell Proteome Responds to a Dietary Flaxseed-intervention and Proteins Identified Suggest a Protective Effect in Atherosclerosis?

Author

Dagmar Fuchs; Regina Piller; Jakob Linseisen; Hannelore Daniel; Uwe Wenzel

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)