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Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study by Laura Michiels; Aline Delva; June van Aalst; Jenny Ceccarini; Wim Vandenberghe; Mathieu Vandenbulcke; Michel Koole; Robin Lemmens; Koen Van Laere is a Neuroscience article available to read on EtoBox.
What is Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study about?
Rationale: 11 C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in vivo proxy of synaptic density. There are discrepancies in postmortem data on stability of synaptic density with healthy aging. In this study, healthy aging and sex as potential modifiers of 11 C-UCB-J binding were investigated in healthy volunteers over 7 adult decades, assuming that the number of SV2A vesicles per synapse is not influenced by age or sex. Methods: 80 healthy volunteers underwent 11 C-UCB-J PET and structural T1 and T2 MR imaging. Grey matter changes with aging were firstly evaluated by voxel-based morphometry (VBM). Parametric 11 C-UCB-J standardized uptake value ratio (SUVR) images were calculated using the centrum semiovale as reference tissue. To correct for atrophy-related partial volume effects, a region-based voxel-wise type partial volume correction (PVC) was applied in FreeSurfer. The correlations of 11 C-UCB-J binding with age and with sex were investigated by a voxelbased and volume-of-interest (VOI)-based approach, and with and without PVC to assess the contribution of underlying morphology chang
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- Author
- Laura Michiels; Aline Delva; June van Aalst; Jenny Ceccarini; Wim Vandenberghe; Mathieu Vandenbulcke; Michel Koole; Robin Lemmens; Koen Van Laere
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)